Phenylpropanoids and polyketides
Medchemexpress LLC Ferulic acid methyl ester | 2309-07-1 | MFCD00017208 | 99.9% | 208.21 g/mol | C11H12O4 | 10 G
Ferulic acid methyl ester is the methyl ester derivative of ferulic acid used as a research reagent. It shows antioxidant and anti-inflammatory properties, is reported to inhibit p38 MAPK and modulate autophagy, and is suitable for biochemical and cell-based studies; batch-specific purity and safety documentation are available from the manufacturer.
- Methyl ester derivative of ferulic acid with antioxidant activity.
- Reported inhibitor of p38 MAPK and modulator of autophagy pathways.
- Cell membrane and brain permeable, suitable for cell-based assays.
- High batch-specific purity with certificate of analysis and SDS documentation available.
- Available in multiple pack sizes for research use, including a 10 g pack.
Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 25 MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent, a thromboxane A2 receptor (TP) antagonist, and a ferroptosis inhibitor. It reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. This compound exhibits anti-asthmatic and anti-epileptic activity.
- Thromboxane A2 receptor (TP) antagonist
- Ferroptosis inhibitor
- Reduces lipid ROS production
- Modulates the systemic xc-/GSH/GPX4 axis
- Inhibits JNK phosphorylation and p53 expression
- Exhibits anti-asthmatic activity
- Exhibits anti-epileptic activity
- For research use only
Cayman Chemical Seratrodast 50mg
A potent antagonist of the TXA2 receptor, blocking specific binding of U-46619 to platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 with an IC50 value of 350 nM; commonly used to study the roles of the TP receptor in animal airways and in tissue samples
Medchemexpress LLC Seratrodast (Standard) | 112665-43-7 | 98.2% | 50 MG
Seratrodast (Standard) is the analytical standard for Seratrodast, designed for research and analytical applications. It functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor, demonstrating anti-asthmatic and anti-epileptic properties.
- Analytical standard for Seratrodast
- Thromboxane A2 receptor (TP) antagonist
- Ferroptosis inhibitor
- Decreases lipid reactive oxygen species (ROS) production
- Regulates the systemic xc-/GSH/GPX4 axis
- Suppresses JNK phosphorylation and p53 expression
- Exhibits anti-asthmatic and anti-epileptic activity
- Commonly utilized in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Seratrodast (Standard) | 112665-43-7 | 98.2% | 100 MG
Seratrodast (Standard) | 112665-43-7 | 98.2% | 100 MG
Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 5 MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent that functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor. It operates by reducing lipid reactive oxygen species (ROS) production, modulating the systemic xc-/GSH/GPX4 axis, and inhibiting JNK phosphorylation and p53 expression. This compound exhibits both anti-asthmatic and anti-epileptic activities.
- Inhibits ferroptosis induced by RSL3 or Erastin in HT22 cells.
- Down-regulates the phosphorylation level of JNK.
- Inhibits ROS generation and lipid peroxidation induced by Erastin in HT22 cells.
- Shows no significant cytotoxicity at concentrations below 10 μM in HT22 cells.
- Prevents cell death in HT22 cells induced by ferroptosis inducers.
- Inhibits neuronal ferroptosis in a pentylenetetrazole-induced mouse epilepsy model.
- Reduces epileptic seizures in vivo.
Sigma Aldrich Fine Chemicals Biosciences Quercetin >=95% (HPLC), solid | 117-39-5 | 100G
Quercetin >=95% (HPLC), solid | Purity: >=95% (HPLC) | Mol Wt: 302.24 | 117-39-5 | 100G
Sigma Aldrich Fine Chemicals Biosciences p-Coumaric acid-1,2,3-13C3 99 atom % 13C, 99% (CP) | 1261170-80-2 | 1MG
p-Coumaric acid-1,2,3-13C3 99 atom % 13C, 99% (CP) | Purity: 99% (CP) | Mol Wt: 167.14 | 1261170-80-2 | 1MG
Apexbio Technology LLC AST 487 630124-46-8 50mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Cayman Chemical SalvIa plebeIa npItrIn 5mg
A flavonoid glycoside with diverse biological activities; protects lard from thermal oxidation at 0.02 and 0.04%; inhibits carrageenin-induced edema and yeast-induced fever in rats; decreases serum levels of triglycerides and LDL, as well as increases serum HDL levels, in a rat model of high-fat diet-induced atherosclerosis at 20 and 50 mg/kg
Apexbio Technology LLC Emamectin Benzoate 155569-91-8 500mg
Emamectin Benzoate (CAS 155569-91-8) is a semi-synthetic derivative targeting insect -aminobutyric acid (GABA) receptors It is designed to interact with these receptors thereby disrupting neurosignaling function Emamectin Benzoate exerts its biological activity primarily through receptor binding that impairs neuronal signaling elevates reactive oxygen species (ROS) production and induces DNA oxidative damage followed by cellular apoptosis In vitro studies have revealed IC50 values typically ranging from low nanomolar to micromolar concentrations depending on insect cell lines and experimental conditions Based on these pharmacological properties Emamectin Benzoate holds research potential in neuroscience toxicology oxidative stress assessments and studies of programmed cell death
eMolecules 6099-03-2 | 2-Methoxycinnamic acid | Ambeed178.187 | C10H10O3 | 98.000 | COc1ccccc1C=CC(O)=O | 5g | 490558558
2-Methoxycinnamic acid | Ambeed | 6099-03-2178.187 | C10H10O3 | 98.000 | COc1ccccc1C=CC(O)=O | 5g | 490558558
TARGETMOL CHEMICALS INC SAKURANETIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sakuranetin a flavanone phytoalexin from ultraviolet-irradiated rice leaves it has antifungal antimutagenic anti-inflammatory and antioxidant effectspurity: 99%
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume